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However, they may havefewer options for assistance, as there are few if any facilities thatoffer shelter to male victims. Studies have revealeda 70–80% reduction in tremor in the off state as well.Improvements in overall motor function in the off medi-cation state range from 50% to 74% in most series, butimprovements in the on medication state show littlechange (0–26%; Rodriguez-Oroz et al., 2000; Deep BrainStimulation for Parkinson’s Disease Study Group, 2001).Hence, it is important to counsel patients that the results ofDBS will likely be equivalent to their best on conditions, asmost of the benefit from STN DBS comes from reductionsin off states and on/off fl uctuations.

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This feature isgenerally most apparent in the earlier phases of AD andbecomes less distinct in the later stages of the disease.

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